This review focuses on recent developments in preservation techniques in liver transplantation. First, we discuss mechanisms of organ injury when using high-risk organs, including donation after circulatory death and steatotic grafts and we summarize pathways of ischemia reperfusion injury together with their link to the immune response. Second, we report on improvement strategies of marginal liver grafts by different machine perfusion concepts and summarize perfusion approaches with recent clinical implementation.
Machine perfusion in liver transplantation : An essential treatment or just an expensive toy? / A.A. Schlegel, M. Kalisvaart, P. Muiesan. - In: MINERVA ANESTESIOLOGICA. - ISSN 0375-9393. - 84:2(2018), pp. 236-245. [10.23736/S0375-9393.17.12016-X]
Machine perfusion in liver transplantation : An essential treatment or just an expensive toy?
P. Muiesan
Ultimo
2018
Abstract
This review focuses on recent developments in preservation techniques in liver transplantation. First, we discuss mechanisms of organ injury when using high-risk organs, including donation after circulatory death and steatotic grafts and we summarize pathways of ischemia reperfusion injury together with their link to the immune response. Second, we report on improvement strategies of marginal liver grafts by different machine perfusion concepts and summarize perfusion approaches with recent clinical implementation.
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