Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailty index based on both phenotypic and recognition memory performances. Hericium erinaceus (H. erinaceus) is a medicinal mushroom that improves recognition memory in mice. By using HPLC-UV-ESI/MS analyses we obtained standardized amounts of erinacine A and hericenones C and D in H. erinaceus extracts, that were tested in our animal model of physiological aging. Two-month oral supplementation with H. erinaceus reversed the age-decline of recognition memory. Proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry in the hippocampus and cerebellum in treated mice supported a positive effect of an H. erinaceus on neurogenesis in frail mice.

Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging / D. Ratto, F. Corana, B. Mannucci, E.C. Priori, F. Cobelli, E. Roda, B. Ferrari, A. Occhinegro, C. Di Iorio, F. De Luca, V. Cesaroni, C. Girometta, M.G. Bottone, E. Savino, H. Kawagishi, P. Rossi. - In: NUTRIENTS. - ISSN 2072-6643. - 11:4(2019), pp. 715.1-715.20. [10.3390/nu11040715]

Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging

E.C. Priori;F. De Luca;
2019

Abstract

Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailty index based on both phenotypic and recognition memory performances. Hericium erinaceus (H. erinaceus) is a medicinal mushroom that improves recognition memory in mice. By using HPLC-UV-ESI/MS analyses we obtained standardized amounts of erinacine A and hericenones C and D in H. erinaceus extracts, that were tested in our animal model of physiological aging. Two-month oral supplementation with H. erinaceus reversed the age-decline of recognition memory. Proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry in the hippocampus and cerebellum in treated mice supported a positive effect of an H. erinaceus on neurogenesis in frail mice.
Aging; Cognitive decline; Erinacines; Hericenones; Hericium erinaceus; Medicinal mushrooms supplementation; Neurogenesis; Phenotypic frailty; Aging; Animals; Cerebellum; Doublecortin Protein; Frailty; Fungal Proteins; Hippocampus; Mice; Neurogenesis; Recognition, Psychology; Agaricales
Settore BIO/06 - Anatomia Comparata e Citologia
Settore BIO/09 - Fisiologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
nutrients-11-00715-v3.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 2.96 MB
Formato Adobe PDF
2.96 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/902299
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 22
social impact