Neuroactive testosterone metabolites synthesized by enzymes 5a-reductase and 3a/3b-hydroxysteroid oxidore-ductase are critical physiological modulators of the central nervous system (CNS) function. Indeed, as discussedin this review, they exert a variety of effects on myelination, brain maturation, neurotransmission, reproductivebehavior, and the stress responses. The expression and synthesis of these enzymes as well as the levels of tes-tosterone derivatives exhibit specific localized regional and sex differences in the CNS and are influenced undervarious physiological and neuropathological conditions. In addition, neuroactive metabolites of testosteroneexert a variety of neuroprotective effects in several neuropathological animal models. Therefore, neuroactive tes-tosterone metabolites might represent an interesting potential therapeutic option to treat some neurological disorders.

Synthesis and actions of 5α-reduced metabolites of testosterone in the nervous system / C. Melcangi, L. Cioffi, S. Diviccaro, A.M. Traish. - In: ANDROGENS. - ISSN 2689-4653. - 2:1(2021 Dec 23), pp. 173-188. [10.1089/andro.2021.0010]

Synthesis and actions of 5α-reduced metabolites of testosterone in the nervous system

C. Melcangi
Primo
;
L. Cioffi
Secondo
;
S. Diviccaro
Penultimo
;
2021

Abstract

Neuroactive testosterone metabolites synthesized by enzymes 5a-reductase and 3a/3b-hydroxysteroid oxidore-ductase are critical physiological modulators of the central nervous system (CNS) function. Indeed, as discussedin this review, they exert a variety of effects on myelination, brain maturation, neurotransmission, reproductivebehavior, and the stress responses. The expression and synthesis of these enzymes as well as the levels of tes-tosterone derivatives exhibit specific localized regional and sex differences in the CNS and are influenced undervarious physiological and neuropathological conditions. In addition, neuroactive metabolites of testosteroneexert a variety of neuroprotective effects in several neuropathological animal models. Therefore, neuroactive tes-tosterone metabolites might represent an interesting potential therapeutic option to treat some neurological disorders.
neuroactive steroids; neurodegenerative disorders; psychiatric disorders; androgen; sex difference
Settore MED/13 - Endocrinologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/901820
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