No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities. Considering the variability in HIV-RNA quantification assays, the biological relevance of viral escape at different thresholds needs to be accurately assessed.

Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities : Is it time to assess the definitions? / M. Trunfio, C. Pinnetti, E. Foca, F. Bai, G. Maffongelli, L. Celani, P. Cinque, A. Celotti, M. Andreoni, A. D'Arminio Monforte, G. D'Ettorre, A. Antinori, A. Calcagno. - In: AIDS. - ISSN 0269-9370. - 33:4(2019 Mar), pp. 759-762. [10.1097/QAD.0000000000002091]

Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities : Is it time to assess the definitions?

F. Bai;A. D'Arminio Monforte;
2019-03

Abstract

No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities. Considering the variability in HIV-RNA quantification assays, the biological relevance of viral escape at different thresholds needs to be accurately assessed.
Adult; Anti-Retroviral Agents; Cerebrospinal Fluid; Cerebrovascular Disorders; Comorbidity; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Plasma; Prevalence; RNA, Viral; Retrospective Studies; Viral Load
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/900974
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