Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group – SIMOne, HIV-HY and STOPSHIV – and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equation. Results: Overall, the mean age was 46.9 ± 10.2 years, and men comprised 73.3% of participants. Comparing 2005, 2011 and 2015, MS was present in 34.5%, 33.0% and 29.3% of PHIV, respectively. Adjusted OR for MS was 0.64 (95% CI: 0.52–0.78) in 2011 and 0.56 (95% CI: 0.46–0.69) in 2015 compared with 2005, while BMI (kg/m2) increased from 23.6 in 2005, 24.5 in 2011 and 24.5 in 2015, with a concomitant increase of being overweight from 29.4% to 39.5% to 39.6% (p < 0.0001). Conclusions: In recent years, PHIV have had a significantly improved metabolic profile compared with previously, despite increasing weight and BMI.
Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade / L. Taramasso, P. Bonfanti, E. Ricci, P. Maggi, G. Orofino, N. Squillace, B. Menzaghi, G. Madeddu, C. Molteni, F. Vichi, E. Riguccini, A. Saracino, C. Santoro, M. Guastavigna, D. Francisci, A. Di Biagio, G.V. De Socio, E. Sarchi, G. Chichino, C. Bolla, C. Bellacosa, G. Angarano, A. Saracino, L. Calza, B. Menzaghi, M. Farinazzo, G. Angioni, M. Gussio, B.M. Celesia, K. Falasca, A. Mastroianni, G. Guadagnino, F. Vichi, E. Salomoni, C. Martinelli, A. Di Biagio, C. Dentone, L. Taramasso, M. Bassetti, G. Cenderello, C. Molteni, G.F. Pellicano, G. Nunnari, L. Valsecchi, L. Cordier, S. Parisini, G. Rizzardini, S. Rusconi, F. Conti, A. Bandera, A. Gori, D. Motta, M. Puoti, P. Bonfanti, G.M. Migliorino, P. Maggi, S. Martini, A. Cascio, M. Trizzino, R. Gulminetti, G.V. De Socio, M. Nofri, D. Francisci, D. Cibelli, G. Parruti, G. Madeddu, M.S. Mameli, G. Orofino, M. Guastavigna. - In: HIV MEDICINE. - ISSN 1464-2662. - 23:1(2022 Jan), pp. 70-79. [10.1111/hiv.13165]
Metabolic syndrome and body weight in people living with HIV infection: analysis of differences observed in three different cohort studies over a decade
L. Taramasso
Primo
;P. BonfantiSecondo
;B. Menzaghi;E. Sarchi;G. Angarano;B. Menzaghi;S. Rusconi;A. Bandera;A. Gori;D. Motta;P. Bonfanti;
2022
Abstract
Objectives: The aim of this study was to assess the incidence of being overweight and metabolic syndrome (MS) among people living with HIV (PHIV) in three different cross-sectional studies conducted over three different periods: 2005, 2011 and 2015. Methods: This was a multi-centre, nationwide study. Data were collected in three studies from the CISAI group – SIMOne, HIV-HY and STOPSHIV – and included a total of 3014 PHIV. Logistic regression [odds ratio (OR), 95% confidence interval (CI)] was used to account for age and gender difference among three groups when comparing MS prevalence and being overweight; potential confounders were accounted for by including them in the regression equation. Results: Overall, the mean age was 46.9 ± 10.2 years, and men comprised 73.3% of participants. Comparing 2005, 2011 and 2015, MS was present in 34.5%, 33.0% and 29.3% of PHIV, respectively. Adjusted OR for MS was 0.64 (95% CI: 0.52–0.78) in 2011 and 0.56 (95% CI: 0.46–0.69) in 2015 compared with 2005, while BMI (kg/m2) increased from 23.6 in 2005, 24.5 in 2011 and 24.5 in 2015, with a concomitant increase of being overweight from 29.4% to 39.5% to 39.6% (p < 0.0001). Conclusions: In recent years, PHIV have had a significantly improved metabolic profile compared with previously, despite increasing weight and BMI.
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