Frailty is an aging related condition, which has been defined as a state of enhanced vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Cognitive impairment is also frequent in older people, often accompanying frailty. Age is the main independent risk factor for both frailty and cognitive impairment, and compelling evidence suggests that similar age-associated mechanisms could underlie both clinical conditions. Accordingly, it has been suggested that frailty and cognitive impairment share common pathways, and some authors proposed “cognitive frailty” as a single complex phenotype. Nevertheless, so far, no clear common underlying pathways have been discovered for both conditions. microRNAs (miRNAs) have emerged as key fine-tuning regulators in most physiological processes, as well as pathological conditions. Importantly, miRNAs have been proposed as both peripheral biomarkers and potential molecular factors involved in physiological and pathological aging. In this review, we discuss the evidence linking changes of selected miRNAs expression with frailty and cognitive impairment. Overall, miR-92a-5p and miR-532-5p, as well as other miRNAs implicated in pathological aging, should be investigated as potential biomarkers (and putative molecular effectors) of cognitive frailty.

The Potential Role of miRNAs in Cognitive Frailty / G. Carini, L. Musazzi, F. Bolzetta, A. Cester, C. Fiorentini, A. Ieraci, S. Maggi, M. Popoli, N. Veronese, A. Barbon. - In: FRONTIERS IN AGING NEUROSCIENCE. - ISSN 1663-4365. - 13:(2021 Nov 12), pp. 763110.1-763110.14. [10.3389/fnagi.2021.763110]

The Potential Role of miRNAs in Cognitive Frailty

A. Ieraci;M. Popoli;
2021-11-12

Abstract

Frailty is an aging related condition, which has been defined as a state of enhanced vulnerability to stressors, leading to a limited capacity to meet homeostatic demands. Cognitive impairment is also frequent in older people, often accompanying frailty. Age is the main independent risk factor for both frailty and cognitive impairment, and compelling evidence suggests that similar age-associated mechanisms could underlie both clinical conditions. Accordingly, it has been suggested that frailty and cognitive impairment share common pathways, and some authors proposed “cognitive frailty” as a single complex phenotype. Nevertheless, so far, no clear common underlying pathways have been discovered for both conditions. microRNAs (miRNAs) have emerged as key fine-tuning regulators in most physiological processes, as well as pathological conditions. Importantly, miRNAs have been proposed as both peripheral biomarkers and potential molecular factors involved in physiological and pathological aging. In this review, we discuss the evidence linking changes of selected miRNAs expression with frailty and cognitive impairment. Overall, miR-92a-5p and miR-532-5p, as well as other miRNAs implicated in pathological aging, should be investigated as potential biomarkers (and putative molecular effectors) of cognitive frailty.
biomarkers; cognitive frailty; cognitive impairment; frailty; MCI (mild cognitive impairment); miRNA–microRNA;
Settore BIO/09 - Fisiologia
CAR_RIC15LMUSA_M - microRNA regulation of synaptic BDNF in the effects of ketamine on dendritic arborization and depressive-like behaviour - MUSAZZI, LAURA - CAR_RIC - Bandi Fondazione Cariplo - 2015
CAR_RIC18MPOPO_01 - MicroRNAs in Frailty-Associated Cognitive Impairment (MATCh-In) - POPOLI, MAURIZIO - CAR_RIC - Bandi Fondazione Cariplo - 2018
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/899637
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