Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In particular, ferritin nanocages (FNs) have been employed for the delivery of a vast array of molecules, ranging from chemotherapeutics to imaging agents, among others. One of the main favorable characteristics of FNs is their intrinsic targeting efficiency toward the Transferrin Receptor 1, which is overexpressed in many tumors. Furthermore, genetic manipulation can be employed to introduce novel variants that are able to improve the loading capacity, targeting capabilities and bio-availability of this versatile drug delivery system. In this review, we discuss the main characteristics of FN and the most recent applications of this promising nanotechnology in the field of oncology with a particular emphasis on the imaging and treatment of solid tumors.

Protein-based nanoparticles for the imaging and treatment of solid tumors : The case of ferritin nanocages, a narrative review / F. Mainini, A. Bonizzi, M. Sevieri, L. Sitia, M. Truffi, F. Corsi, S. Mazzucchelli. - In: PHARMACEUTICS. - ISSN 1999-4923. - 13:12(2021 Nov 25), pp. 2000.1-2000.19. [10.3390/pharmaceutics13122000]

Protein-based nanoparticles for the imaging and treatment of solid tumors : The case of ferritin nanocages, a narrative review

F. Mainini
Primo
;
A. Bonizzi;M. Sevieri;L. Sitia;M. Truffi;F. Corsi
Penultimo
;
S. Mazzucchelli
Ultimo
2021-11-25

Abstract

Protein nanocages have been studied extensively, due to their unique architecture, exceptional biocompatibility and highly customization capabilities. In particular, ferritin nanocages (FNs) have been employed for the delivery of a vast array of molecules, ranging from chemotherapeutics to imaging agents, among others. One of the main favorable characteristics of FNs is their intrinsic targeting efficiency toward the Transferrin Receptor 1, which is overexpressed in many tumors. Furthermore, genetic manipulation can be employed to introduce novel variants that are able to improve the loading capacity, targeting capabilities and bio-availability of this versatile drug delivery system. In this review, we discuss the main characteristics of FN and the most recent applications of this promising nanotechnology in the field of oncology with a particular emphasis on the imaging and treatment of solid tumors.
cancer; drug delivery; ferritin; imaging; tumor targeting
Settore BIO/10 - Biochimica
Article (author)
File in questo prodotto:
File Dimensione Formato  
pharmaceutics-13-02000.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 2.22 MB
Formato Adobe PDF
2.22 MB Adobe PDF Visualizza/Apri
pharmaceutics-1469204 _revised.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 945.82 kB
Formato Adobe PDF
945.82 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/899278
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact