Natural killer (NK) and dendritic cells (DCs) are innate immune cells that play a crucial role in anti-tumor immunity. NK cells kill tumor cells through direct cytotoxicity and cytokine secretion. DCs are needed for the activation of adaptive immune responses against tumor cells. Both NK cells and DCs are subdivided in several subsets endowed with specialized effector functions. Crosstalk between NK cells and DCs leads to the reciprocal control of their activation and polar-ization of immune responses. In this review, we describe the role of NK cells and DCs in liver cancer, focusing on the mechanisms involved in their reciprocal control and activation. In this context, intrahepatic NK cells and DCs present unique immunological features due to the constant exposure to non-self-circulating antigens. These interactions may play a fundamental role in the pathology of primary liver cancer, namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Additionally, the implications of these immune changes are relevant from the perspective of improve the cancer immunotherapy strategies in HCC and ICC patients.

Natural killer-dendritic cell Interactions in liver cancer: implications for immunotherapy / V. Cazzetta, S. Franzese, C. Carenza, S.A.M. Della Bella, J. Mikulak, D. Mavilio. - In: CANCERS. - ISSN 2072-6694. - 13:9(2021 May 01), pp. 2184.1-2184.27. [10.3390/cancers13092184]

Natural killer-dendritic cell Interactions in liver cancer: implications for immunotherapy

V. Cazzetta
Co-primo
;
S. Franzese
Co-primo
;
C. Carenza;S.A.M. Della Bella;J. Mikulak;D. Mavilio
Ultimo
2021-05-01

Abstract

Natural killer (NK) and dendritic cells (DCs) are innate immune cells that play a crucial role in anti-tumor immunity. NK cells kill tumor cells through direct cytotoxicity and cytokine secretion. DCs are needed for the activation of adaptive immune responses against tumor cells. Both NK cells and DCs are subdivided in several subsets endowed with specialized effector functions. Crosstalk between NK cells and DCs leads to the reciprocal control of their activation and polar-ization of immune responses. In this review, we describe the role of NK cells and DCs in liver cancer, focusing on the mechanisms involved in their reciprocal control and activation. In this context, intrahepatic NK cells and DCs present unique immunological features due to the constant exposure to non-self-circulating antigens. These interactions may play a fundamental role in the pathology of primary liver cancer, namely hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Additionally, the implications of these immune changes are relevant from the perspective of improve the cancer immunotherapy strategies in HCC and ICC patients.
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/898759
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