Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but also a novel identified target for preventive and curative medicine. The goal of this review is to focus on the novelties concerning TXNIP. After an overview in TXNIP involvement in oxidative stress, inflammation and metabolism, the remainder of this review presents the clues used to define TXNIP as a new marker at the genetic, blood, or ischemic site level in the context of cardiovascular and ischemic diseases.
The emerging role of TXNIP in ischemic and cardiovascular diseases; a novel marker and therapeutic target / A. Domingues, J. Jolibois, P.M. de Rouge, V. Nivet-Antoine. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:4(2021), pp. 1693.1-1693.25. [10.3390/ijms22041693]
The emerging role of TXNIP in ischemic and cardiovascular diseases; a novel marker and therapeutic target
A. DominguesPrimo
;
2021
Abstract
Thioredoxin interacting protein (TXNIP) is a metabolism-oxidative-and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but also a novel identified target for preventive and curative medicine. The goal of this review is to focus on the novelties concerning TXNIP. After an overview in TXNIP involvement in oxidative stress, inflammation and metabolism, the remainder of this review presents the clues used to define TXNIP as a new marker at the genetic, blood, or ischemic site level in the context of cardiovascular and ischemic diseases.File | Dimensione | Formato | |
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