The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs), so called dental-derived stem cells (D-dSCs) with self-renewing and multilineage differentiation capabilities. D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment. Altogether, this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes, and offers information regarding the available scientific data and possible applications.

Dental-derived stem cells and biowaste biomaterials : What’s next in bone regenerative medicine applications / M.D. Cosola, S. Cantore, M.G. Balzanelli, C.G. Isacco, K.C.D. Nguyen, R. Saini, A. Malcangi, M. Tumedei, M. Ambrosino, A. Mancini, S. Scacco, R. Nocini, L. Santacroce, A. Ballini, E. Brauner. - In: BIOCELL. - ISSN 0327-9545. - 46:3(2022), pp. 923-929. [10.32604/biocell.2022.018409]

Dental-derived stem cells and biowaste biomaterials : What’s next in bone regenerative medicine applications

M. Tumedei;
2022

Abstract

The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs), so called dental-derived stem cells (D-dSCs) with self-renewing and multilineage differentiation capabilities. D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment. Altogether, this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes, and offers information regarding the available scientific data and possible applications.
Biomaterials; Bone regenerative medicine; Dental-derived stem cells; Secretome; Waste medicine
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/28 - Malattie Odontostomatologiche
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/896638
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