Patients with relapsed/refractory (R/R) peripheral T-cell lymphoma (PTCL) have a poor prognosis, with an expected survival of less than 1 year using standard salvage therapies. Recent advances in our understanding of the biology of PTCL have led to identifying B-Cell Lymphoma 2 (BCL2) protein as a potential therapeutic target. BLC2 inhibitor venetoclax was investigated in a prospective phase II trial in patients with BCL2-positive R/R PTCL after at least one previous standard line of treatment (NCT03552692). Venetoclax given alone at a dosage of 800 mg/day resulted in one complete response (CR) and two stable diseases (SDs) among 17 enrolled patients. The majority of patients (88.2%) interrupted the treatment due to disease progression. No relationship with BCL2 expression was documented. At a median follow-up of 8 months, two patients are currently still on treatment (one CR and one SD). No case of tumor lysis syndrome was registered. Therefore, venetoclax monotherapy shows activity in a minority of patients whose biological characteristics have not yet been identified. Clinical Trial Registration: www.clinicaltrials.gov (NCT03552692, EudraCT number 2017-004630-29).
Venetoclax Shows Low Therapeutic Activity in BCL2-Positive Relapsed/Refractory Peripheral T-Cell Lymphoma : A Phase 2 Study of the Fondazione Italiana Linfomi / L. Ballotta, P.L. Zinzani, S. Pileri, R. Bruna, M. Tani, B. Casadei, V. Tabanelli, S. Volpetti, S. Luminari, P. Corradini, E. Lucchini, M.C. Tisi, M. Merli, A. Re, M. Varettoni, E.A. Pesce, F. Zaja. - In: FRONTIERS IN ONCOLOGY. - ISSN 2234-943X. - 11(2021 Dec), pp. 789891.1-789891.7. [10.3389/fonc.2021.789891]
|Titolo:||Venetoclax Shows Low Therapeutic Activity in BCL2-Positive Relapsed/Refractory Peripheral T-Cell Lymphoma : A Phase 2 Study of the Fondazione Italiana Linfomi|
|Parole Chiave:||BCL2 inhibition; BCL2 protein; peripheral T-cell lymphoma; relapsed/refractory; venetoclax|
|Settore Scientifico Disciplinare:||Settore MED/15 - Malattie del Sangue|
|Data di pubblicazione:||dic-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3389/fonc.2021.789891|
|Appare nelle tipologie:||01 - Articolo su periodico|