Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera from 49 COVID-19 patients were analyzed by untargeted lipidomics. Patients were clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) and age. COVID-19 patients exhibited remarkable and distinctive dyslipidemia for each prognostic factor associated with reduced defense against oxidative stress. When patients were clustered by outcome (7 days), a peculiar lipidome signature was detected with an overall increase of 29 lipid species, including—among others—four ceramide and three sulfatide species, univocally related to this analysis. Considering the lipids that were affected by all the prognostic factors, we found one sphingomyelin related to inflammation and viral infection of the respiratory tract and two sphingomyelins, that are independently related to patients' age, and they appear as candidate biomarkers to monitor disease progression and severity. Although preliminary and needing validation, this report pioneers the translation of lipidome signatures to link the effects of five critical clinical prognostic factors with the patients' outcomes.

Link between serum lipid signature and prognostic factors in COVID-19 patients / M. Dei Cas, S. Ottolenghi, C. Morano, R. Rinaldo, G. Roda, D. Chiumello, S. Centanni, M. Samaja, R. Paroni. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 11:1(2021 Nov 04), pp. 21633.1-21633.11. [10.1038/s41598-021-00755-z]

Link between serum lipid signature and prognostic factors in COVID-19 patients

M. Dei Cas
Primo
;
S. Ottolenghi
Secondo
;
C. Morano;R. Rinaldo;G. Roda;D. Chiumello;S. Centanni;M. Samaja
Penultimo
;
R. Paroni
Ultimo
2021

Abstract

Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera from 49 COVID-19 patients were analyzed by untargeted lipidomics. Patients were clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) and age. COVID-19 patients exhibited remarkable and distinctive dyslipidemia for each prognostic factor associated with reduced defense against oxidative stress. When patients were clustered by outcome (7 days), a peculiar lipidome signature was detected with an overall increase of 29 lipid species, including—among others—four ceramide and three sulfatide species, univocally related to this analysis. Considering the lipids that were affected by all the prognostic factors, we found one sphingomyelin related to inflammation and viral infection of the respiratory tract and two sphingomyelins, that are independently related to patients' age, and they appear as candidate biomarkers to monitor disease progression and severity. Although preliminary and needing validation, this report pioneers the translation of lipidome signatures to link the effects of five critical clinical prognostic factors with the patients' outcomes.
Adult; Aged; Biomarkers; COVID-19; Dyslipidemias; Female; Humans; Italy; Lipidomics; Lipids; Male; Middle Aged; Oxidative Stress; Prognosis; SARS-CoV-2; Serum; Sphingomyelins
Settore BIO/10 - Biochimica
Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Settore MED/41 - Anestesiologia
Settore MED/10 - Malattie dell'Apparato Respiratorio
Settore MED/17 - Malattie Infettive
PNRA20MSAMA_01 - Impatto dell’ambiente Antartico sull’omeostasi, psicologia, fisiologia e immunità dell’uomo - SAMAJA, MICHELE - PNRA - Programma Nazionale di Ricerca in Antartide (MIUR) - 2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/891281
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