Spiro-epoxyoxindoles containing an unsubstituted methylene fragment in the oxirane ring are excellent building blocks in organic synthesis due to the high reactivity conferred by the three-membered oxygenated cycle. In this minireview, a concise survey of the methods of their synthesis and examples of reactivity with carbon and nitrogen nucleophiles is presented, with a particular focus on the stereochemical aspects. The review covers the literature for the last twenty years.
Recent advances in the synthesis and reactivity of spiro-epoxyoxindoles / S. Monticelli, L. Castoldi, S. Touqeer, M. Miele, E. Urban, V. Pace. - In: CHEMISTRY OF HETEROCYCLIC COMPOUNDS. - ISSN 0009-3122. - 54:4(2018 Jun 07), pp. 389-393. [10.1007/s10593-018-2280-4]
Recent advances in the synthesis and reactivity of spiro-epoxyoxindoles
L. CastoldiSecondo
;
2018
Abstract
Spiro-epoxyoxindoles containing an unsubstituted methylene fragment in the oxirane ring are excellent building blocks in organic synthesis due to the high reactivity conferred by the three-membered oxygenated cycle. In this minireview, a concise survey of the methods of their synthesis and examples of reactivity with carbon and nitrogen nucleophiles is presented, with a particular focus on the stereochemical aspects. The review covers the literature for the last twenty years.
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