A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.
Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF / A.D. Mamuye, S. Monticelli, L. Castoldi, W. Holzer, V. Pace. - In: GREEN CHEMISTRY. - ISSN 1463-9262. - 17:8(2015), pp. 4194-4197. [10.1039/c5gc01002k]
Eco-friendly chemoselective N-functionalization of isatins mediated by supported KF in 2-MeTHF
L. Castoldi;
2015
Abstract
A sustainable, efficient method for the chemoselective N-functionalization of isatins based on the use of KF-Celite in 2-methyltetrahydrofuran is reported. Notably, the protocol allows reactions with a wide range of electrophiles such as alkyl halides, isocyanates and Michael acceptors.
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