The advent of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival in patients with peritoneal surface malignancies. Not surprisingly, there is now a growing interest on the possible means to preserve fertility to ensure future childbearing. In this study, we report on five women with peritoneal surface malignancies who performed ovarian hyper-stimulation and oocytes cryostorage prior to undergo CRS and HIPEC. The presence of the disease complicated follicular growth monitoring but the oocytes retrievals could be always performed and were uneventful. At last follow-up, all women were alive and disease-free. None has yet returned to thaw her oocytes. Overall, these cases suggest that oocytes cryopreservation before CRS and HIPEC should be considered.

Fertility preservation in women with peritoneal surface malignancies: A case series / F. Filippi, S. Kusamura, F. Martinelli, E. Somigliana, M. Deraco. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - 47:11(2021 Nov), pp. 2948-2951. [10.1016/j.ejso.2021.03.259]

Fertility preservation in women with peritoneal surface malignancies: A case series

E. Somigliana
Penultimo
;
2021

Abstract

The advent of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival in patients with peritoneal surface malignancies. Not surprisingly, there is now a growing interest on the possible means to preserve fertility to ensure future childbearing. In this study, we report on five women with peritoneal surface malignancies who performed ovarian hyper-stimulation and oocytes cryostorage prior to undergo CRS and HIPEC. The presence of the disease complicated follicular growth monitoring but the oocytes retrievals could be always performed and were uneventful. At last follow-up, all women were alive and disease-free. None has yet returned to thaw her oocytes. Overall, these cases suggest that oocytes cryopreservation before CRS and HIPEC should be considered.
Cytoreductive surgery; Fertility preservation; Hyperthermic intraperitoneal chemotherapy; Infertility; Oocyte; Primary peritoneal disease
Settore MED/40 - Ginecologia e Ostetricia
Article (author)
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0748798321004042-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 445.77 kB
Formato Adobe PDF
445.77 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Filippi et al., Text CLEAN.pdf

embargo fino al 01/11/2022

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 233.89 kB
Formato Adobe PDF
233.89 kB Adobe PDF Visualizza/Apri
Filippi et al.,Tables.pdf

accesso aperto

Tipologia: Altro
Dimensione 110.08 kB
Formato Adobe PDF
110.08 kB Adobe PDF Visualizza/Apri
Filippi et al., Figure 1.pdf

accesso aperto

Tipologia: Altro
Dimensione 107.41 kB
Formato Adobe PDF
107.41 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/890300
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 1
social impact