Intraoperative injury to the recurrent laryngeal nerve (RLN) can cause vocal cord paralysis, which interferes with speech and can potentially interfere with breathing. In recent years, intraoperative neural monitoring (IONM) has been widely adapted as an adjunct technique to localize the RLN, detect RLN injury, and predict vocal cord function during the operations. Many studies have also used animal models to investigate new applications of IONM technology and to develop reliable strategies for preventing intraoperative RLN injury. The aim of this article is to introduce a standard protocol for using a porcine model in IONM research. The article demonstrates the procedures for inducing general anesthesia, performing tracheal intubation, and experimental design to investigate the electrophysiological characteristics of RLN injuries. Applications of this protocol can improve overall efficacy in implementing the 3R principle (replacement, reduction and refinement) in porcine IONM studies.

Porcine model in intra-operative neural monitoring in thyroid surgery / C. Wu, T. Huang, H. Chen, H. Chen, T. Tsai, P. Ying Chang, Y. Lin, H. Tseng, P. Hun, X. Liu, H. Sun, G.W. Randolph, G. Dionigi, F. Chiang, I. Lu. - In: JOURNAL OF VISUALIZED EXPERIMENTS. - ISSN 1940-087X. - 144(2019 Feb), pp. e57919.1-e57919.10. [10.3791/57919]

Porcine model in intra-operative neural monitoring in thyroid surgery

G. Dionigi;
2019

Abstract

Intraoperative injury to the recurrent laryngeal nerve (RLN) can cause vocal cord paralysis, which interferes with speech and can potentially interfere with breathing. In recent years, intraoperative neural monitoring (IONM) has been widely adapted as an adjunct technique to localize the RLN, detect RLN injury, and predict vocal cord function during the operations. Many studies have also used animal models to investigate new applications of IONM technology and to develop reliable strategies for preventing intraoperative RLN injury. The aim of this article is to introduce a standard protocol for using a porcine model in IONM research. The article demonstrates the procedures for inducing general anesthesia, performing tracheal intubation, and experimental design to investigate the electrophysiological characteristics of RLN injuries. Applications of this protocol can improve overall efficacy in implementing the 3R principle (replacement, reduction and refinement) in porcine IONM studies.
medicine; Issue 144Intraoperative neural monitoringrecurrent laryngeal nerveexternal branch of the superior laryngeal nervevagus nervethyroid surgeryanimal studyporcine model
Settore MED/18 - Chirurgia Generale
2018
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/888733
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