Current guidelines recommend reducing the daily intake of dietary fats for the prevention of ischemic cardiovascular diseases (CVDs). Avoiding saturated fats while increasing the intake of mono-or polyunsaturated fatty acids has been for long time the cornerstone of dietary approaches in cardiovascular prevention, mainly due to the metabolic effects of these molecules. However, recently, this approach has been critically revised. The experimental evidence, in fact, supports the concept that the pro-or anti-inflammatory potential of different dietary fats contributes to atherogenic or anti-atherogenic cellular and molecular processes beyond (or in addition to) their metabolic effects. All these aspects are hardly translatable into clinics when trying to find connections between the pro-/anti-inflammatory potential of dietary lipids and their effects on CVD outcomes. Interventional trials, although providing stronger potential for causal inference, are typically small sample-sized, and they have short follow-up, noncompliance, and high attrition rates. Besides, observational studies are con-founded by a number of variables and the quantification of dietary intakes is far from optimal. A better understanding of the anatomic and physiological barriers for the absorption and the players involved in the metabolism of dietary lipids (e.g., gut microbiota) might be an alternative strategy in the attempt to provide a first step towards a personalized dietary approach in CVD prevention.

Molecular immune-inflammatory connections between dietary fats and atherosclerotic cardiovascular disease : which translation into clinics? / E. Mattavelli, A.L. Catapano, A. Baragetti. - In: NUTRIENTS. - ISSN 2072-6643. - 13:11(2021 Oct 25), pp. 3768.1-3768.22. [10.3390/nu13113768]

Molecular immune-inflammatory connections between dietary fats and atherosclerotic cardiovascular disease : which translation into clinics?

E. Mattavelli
Primo
;
A.L. Catapano
Secondo
;
A. Baragetti
Ultimo
Conceptualization
2021

Abstract

Current guidelines recommend reducing the daily intake of dietary fats for the prevention of ischemic cardiovascular diseases (CVDs). Avoiding saturated fats while increasing the intake of mono-or polyunsaturated fatty acids has been for long time the cornerstone of dietary approaches in cardiovascular prevention, mainly due to the metabolic effects of these molecules. However, recently, this approach has been critically revised. The experimental evidence, in fact, supports the concept that the pro-or anti-inflammatory potential of different dietary fats contributes to atherogenic or anti-atherogenic cellular and molecular processes beyond (or in addition to) their metabolic effects. All these aspects are hardly translatable into clinics when trying to find connections between the pro-/anti-inflammatory potential of dietary lipids and their effects on CVD outcomes. Interventional trials, although providing stronger potential for causal inference, are typically small sample-sized, and they have short follow-up, noncompliance, and high attrition rates. Besides, observational studies are con-founded by a number of variables and the quantification of dietary intakes is far from optimal. A better understanding of the anatomic and physiological barriers for the absorption and the players involved in the metabolism of dietary lipids (e.g., gut microbiota) might be an alternative strategy in the attempt to provide a first step towards a personalized dietary approach in CVD prevention.
cardiovascular disease; dietary lipids; immune-inflammation; microbiota
Settore BIO/14 - Farmacologia
RL_DG-UNI18ACATA_01 - Studio e messa a punto di nuovi prodotti pro-e prebiotici per la prevenzione ed il trattamento di patologie infiammatorie quali la sindrome del colon irritabile e la dermatite atopica (SCIDA) - CATAPANO, ALBERICO LUIGI - RL_DG-UNI - Bandi DG Università, ricerca e open innovation - 2018
PRIN201719ACATA_01 - Low density lipoprotein receptor (LDLR)-independent effects of proprotein convertase subtilisin/kexin type 9 (PCSK9): role in modulating insulin-resistance, ectopic fat accumulation and low-grade inflammation - CATAPANO, ALBERICO LUIGI - PRIN2017 - PRIN bando 2017 - 2019
AL_RIC19ABARA_01 - Potere pro-infiammatorio della dieta sulla composizione del microbiota intestinale e relazione con la malattia cardiovascolare ischemica - BARAGETTI, ANDREA - AL_RIC - Bandi da altri enti di ricerca - 2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/887456
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