For a long time, high-density lipoprotein cholesterol (HDL-C) has been regarded as a cardiovascular disease (CVD) protective factor. Recently, several epidemiological studies, while confirming low plasma levels of HDL-C as an established predictive biomarker for atherosclerotic CVD, indicated that not only people at the lowest levels but also those with high HDL-C levels are at increased risk of cardiovascular (CV) mortality. This “U-shaped” association has further fueled the discussion on the pathophysiological role of HDL in CVD. In fact, genetic studies, Mendelian randomization approaches, and clinical trials have challenged the notion of HDL-C levels being causally linked to CVD protection, independent of the cholesterol content in low-density lipoproteins (LDL-C). These findings have prompted a reconsideration of the biological functions of HDL that can be summarized with the word “HDL functionality”, a term that embraces the many reported biological activities beyond the so-called reverse cholesterol transport, to explain this lack of correlation between HDL levels and CVD. All these aspects are summarized and critically discussed in this review, in an attempt to provide a background scenario for the “HDL story”, a lipoprotein still in search of a role.

HDL in atherosclerotic cardiovascular disease : In search of a role / M. Casula, O. Colpani, S. Xie, A.L. Catapano, A. Baragetti. - In: CELLS. - ISSN 2073-4409. - 10:8(2021 Jul 23), pp. 1869.1-1869.17. [10.3390/cells10081869]

HDL in atherosclerotic cardiovascular disease : In search of a role

M. Casula
Primo
;
O. Colpani
Secondo
;
S. Xie;A.L. Catapano
Penultimo
;
A. Baragetti
Ultimo
2021

Abstract

For a long time, high-density lipoprotein cholesterol (HDL-C) has been regarded as a cardiovascular disease (CVD) protective factor. Recently, several epidemiological studies, while confirming low plasma levels of HDL-C as an established predictive biomarker for atherosclerotic CVD, indicated that not only people at the lowest levels but also those with high HDL-C levels are at increased risk of cardiovascular (CV) mortality. This “U-shaped” association has further fueled the discussion on the pathophysiological role of HDL in CVD. In fact, genetic studies, Mendelian randomization approaches, and clinical trials have challenged the notion of HDL-C levels being causally linked to CVD protection, independent of the cholesterol content in low-density lipoproteins (LDL-C). These findings have prompted a reconsideration of the biological functions of HDL that can be summarized with the word “HDL functionality”, a term that embraces the many reported biological activities beyond the so-called reverse cholesterol transport, to explain this lack of correlation between HDL levels and CVD. All these aspects are summarized and critically discussed in this review, in an attempt to provide a background scenario for the “HDL story”, a lipoprotein still in search of a role.
genetics; HDL cholesterol; HDL lipoproteins; pharmacological trials; animals; arteries; atherosclerosis; biomarkers; cholesterol, HDL; dyslipidemias; genetic predisposition to disease; genetic variation; heart disease risk factors; humans; plaque, atherosclerotic; prognosis; protective factors; risk assessment
Settore BIO/14 - Farmacologia
AL_RIC19ABARA_01 - Potere pro-infiammatorio della dieta sulla composizione del microbiota intestinale e relazione con la malattia cardiovascolare ischemica - BARAGETTI, ANDREA - AL_RIC - Bandi da altri enti di ricerca - 2019
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/887450
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