A straightforward chromatography-free preparation of Weinreb amides starting from acid halides has been achieved in the biphasic medium 2-MeTHF/water. Analytically pure compounds were isolated in excellent yields simply after removal of 2-MeTHF, which absolutely avoids the use of any contaminant organic solvent within the whole process due to its (practically) immiscibility with water.
Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water / V. Pace, L. Castoldi, A.R. Alcantara, W. Holzer. - In: RSC ADVANCES. - ISSN 2046-2069. - 3:26(2013 Apr 15), pp. 10158-10162. [10.1039/c3ra41262h]
Highly efficient and environmentally benign preparation of Weinreb amides in the biphasic system 2-MeTHF/water
L. Castoldi;
2013
Abstract
A straightforward chromatography-free preparation of Weinreb amides starting from acid halides has been achieved in the biphasic medium 2-MeTHF/water. Analytically pure compounds were isolated in excellent yields simply after removal of 2-MeTHF, which absolutely avoids the use of any contaminant organic solvent within the whole process due to its (practically) immiscibility with water.
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