Papillary thyroid carcinoma (PTC) is a heterogeneous group with differing pathogenesis and prognosis of the individual subtypes. In addition, a tumor entity has been spun off, now referred to as "noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP). A recent study, based on a comprenhensive evaluation of a prospective multicenter NIFTP-based retrospective study, was intended to clarify whether NIFTP can metastasize and thus justify a reduced resection rate compared to classical PTC. For 3 reasons, Authors nicely recommend caution regarding a limited thyroid procedure (i.e lobectomy vs. completion thyroidectomy): i) in the current literature, lymph node metastase have benn described in 10 patients with NIFTP, and in 1 patient lung metastases. ii) As reported for the first time in this study, nearly one-fifth of patients have NIFTP-associated PTMC with unclear potential for metastasis. iii) Observation periods are still relatively short and so far, there are no agreed follow-up standards.

Recommended Surgery for >1 cm Noninvasive Follicular Neoplasia with Papillary-Like Nuclear Features (NIFTP) / A. Pontin, E. Gagliano, G. Dionigi. - In: JOURNAL OF ENDOCRINE SURGERY. - ISSN 2508-8149. - 19:4(2019), pp. 159-161. [10.16956/jes.2019.19.4.159]

Recommended Surgery for >1 cm Noninvasive Follicular Neoplasia with Papillary-Like Nuclear Features (NIFTP)

G. Dionigi
Ultimo
2019

Abstract

Papillary thyroid carcinoma (PTC) is a heterogeneous group with differing pathogenesis and prognosis of the individual subtypes. In addition, a tumor entity has been spun off, now referred to as "noninvasive follicular neoplasm with papillary-like nuclear features (NIFTP). A recent study, based on a comprenhensive evaluation of a prospective multicenter NIFTP-based retrospective study, was intended to clarify whether NIFTP can metastasize and thus justify a reduced resection rate compared to classical PTC. For 3 reasons, Authors nicely recommend caution regarding a limited thyroid procedure (i.e lobectomy vs. completion thyroidectomy): i) in the current literature, lymph node metastase have benn described in 10 patients with NIFTP, and in 1 patient lung metastases. ii) As reported for the first time in this study, nearly one-fifth of patients have NIFTP-associated PTMC with unclear potential for metastasis. iii) Observation periods are still relatively short and so far, there are no agreed follow-up standards.
Thyroid surgery; Noninvasive follicular neoplasia; Papillary-like nuclear features; Thyroid gland
Settore MED/18 - Chirurgia Generale
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/885804
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