The understanding of the molecular pathogenesis of thyroid cancers paved the way for the development of novel cutting-edge therapeutic agents; for this reason, a more tailored disease management will be possible.Thyroid cancer is the most prevalent neoplasm among endocrine tumors, presenting an increasing incidence trend over the last few years. Multikinase inhibitors have shown improved clinical outcome and implemented tumor response in advanced thyroid cancer. Cancer is still an enigmatic, complex, heterogeneous, rapidly evolving, rapidly shifting, fast adapting and unfortunately not completely understood enemy.

Targeted agents for advanced thyroid cancer: "knowledge is power"- the role of multikinase inhibitors / A. Mangano, H.Y. Kim, G.D. Lianos, D.H. Roukos, G. Dionigi. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 10:14(2014), pp. 2099-2102. [10.2217/fon.14.137]

Targeted agents for advanced thyroid cancer: "knowledge is power"- the role of multikinase inhibitors

G. Dionigi
Ultimo
2014

Abstract

The understanding of the molecular pathogenesis of thyroid cancers paved the way for the development of novel cutting-edge therapeutic agents; for this reason, a more tailored disease management will be possible.Thyroid cancer is the most prevalent neoplasm among endocrine tumors, presenting an increasing incidence trend over the last few years. Multikinase inhibitors have shown improved clinical outcome and implemented tumor response in advanced thyroid cancer. Cancer is still an enigmatic, complex, heterogeneous, rapidly evolving, rapidly shifting, fast adapting and unfortunately not completely understood enemy.
advanced thyroid cancer; intertumor heterogeneity; intratumor heterogeneity; multikinase inhibitor; targeted agent; Antineoplastic Agents; Enzyme Inhibitors; Humans; Phosphotransferases; Thyroid Neoplasms; Molecular Targeted Therapy; Oncology; Cancer Research; Medicine (all)
Settore MED/18 - Chirurgia Generale
Article (author)
File in questo prodotto:
File Dimensione Formato  
lianos2014.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 1.09 MB
Formato Adobe PDF
1.09 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/885007
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact