Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives.

Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer / G. Dionigi, L. Boni, F. Rovera, S. Rausei, S. Cuffari, G. Cantone, A. Bacuzzi, R. Dionigi. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - 15:32(2009), pp. 3976-3983. [10.3748/wjg.15.3976]

Effect of perioperative blood transfusion on clinical outcomes in hepatic surgery for cancer

G. Dionigi
Primo
;
L. Boni;
2009

Abstract

Allogeneic blood transfusion during liver resection for malignancies has been associated with an increased incidence of different types of complications: infectious complications, tumor recurrence, decreased survival. Even if there is clear evidence of transfusion-induced immunosuppression, it is difficult to demonstrate that transfusion is the only determinant factor that decisively affects the outcome. In any case there are several motivations to reduce the practice of blood transfusion. The advantages and drawbacks of different transfusion alternatives are reviewed here, emphasizing that surgeons and anesthetists who practice in centers with a high volume of liver resections, should be familiar with all the possible alternatives.
Blood transfusion; Blood products; Allogeneic blood transfusion; Intraoperative autotransfusion; Preoperative autologous blood donation; Intraoperative isovolemic hemodilution; Infectious complications; Liver resection; Hepatocellular carcinoma
Settore MED/18 - Chirurgia Generale
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/884582
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