Background: Evolving surgical technology and medical treatment have led to an expansion of indications to enable resection of large hepatic tumours with involvement of other abdominal structures. Methods: Twelve extended liver and abdominal resections, either ex situ with auto-transplantation of the liver remnant or ante situm with veno-venous bypass (VVBP) were performed between 2016 and 2018. We describe our preoperative assessment, compare surgical strategies and assess outcomes. Results: The median age of the 10 adult patients was 50.5 years with a majority suffering from sarcoma-like tumours. The two paediatric patients were 3 and 8 years of age, both with hepatoblastoma. Two patients underwent ex situ resections with auto-transplantation of the liver remnant, and nine patients had ante situm tumour removal with the use of VVBP in four. All patients achieved a good immediate liver function. Local infection and acute kidney injury were found in two patients. One patient underwent biliary reconstruction for bile leak. Tumour recurrence was seen in seven patients (58.3%), with four lung metastases. Five patients died from tumour recurrence (41.7%) during the follow-up. Conclusion: Extreme liver resections should be performed in experienced centres, where surgical subspecialties are available with access to cardiovascular support. Additionally, experience in split and living-donor liver transplantation is beneficial.

Outcome after ex situ or ante situm liver resection with hypothermic perfusion and auto-transplantation : A single-centre experience in adult and paediatric patients / A. Schlegel, Y. Sakuraoka, K. Motwani, D. Gourevitch, K. Sharif, J. Isaac, M. Almond, A. Desai, P. Muiesan. - In: JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0022-4790. - 122:6(2020), pp. 1122-1131. [10.1002/jso.26116]

Outcome after ex situ or ante situm liver resection with hypothermic perfusion and auto-transplantation : A single-centre experience in adult and paediatric patients

P. Muiesan
Ultimo
2020

Abstract

Background: Evolving surgical technology and medical treatment have led to an expansion of indications to enable resection of large hepatic tumours with involvement of other abdominal structures. Methods: Twelve extended liver and abdominal resections, either ex situ with auto-transplantation of the liver remnant or ante situm with veno-venous bypass (VVBP) were performed between 2016 and 2018. We describe our preoperative assessment, compare surgical strategies and assess outcomes. Results: The median age of the 10 adult patients was 50.5 years with a majority suffering from sarcoma-like tumours. The two paediatric patients were 3 and 8 years of age, both with hepatoblastoma. Two patients underwent ex situ resections with auto-transplantation of the liver remnant, and nine patients had ante situm tumour removal with the use of VVBP in four. All patients achieved a good immediate liver function. Local infection and acute kidney injury were found in two patients. One patient underwent biliary reconstruction for bile leak. Tumour recurrence was seen in seven patients (58.3%), with four lung metastases. Five patients died from tumour recurrence (41.7%) during the follow-up. Conclusion: Extreme liver resections should be performed in experienced centres, where surgical subspecialties are available with access to cardiovascular support. Additionally, experience in split and living-donor liver transplantation is beneficial.
ante situm; auto-transplantation; ex situ; hypothermic perfusion; Adult; Aged; Child; Child, Preschool; Female; Follow-Up Studies; Hepatectomy; Humans; Hypothermia, Induced; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Living Donors; Perfusion
Settore MED/18 - Chirurgia Generale
Article (author)
File in questo prodotto:
File Dimensione Formato  
2020-Outcome after ex situ or ante situm.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 3.82 MB
Formato Adobe PDF
3.82 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/883150
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact