We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The patient then developed liver metastasis and a breast lesion, displaying high estrogen receptor (ER) expression and harboring the same EGFR mutation. From the radiological studies, it was not possible to make a differential diagnosis between primary breast cancer and breast metastasis from lung cancer. After the removal of the breast nodule, thanks to the clinical history, radiology, and above all, molecular and immunohistochemical investigations, a diagnosis of breast metastasis from lung adenocarcinoma was made. This case emphasizes the importance of a comprehensive clinical, pathological, and molecular analysis in the differential diagnosis between primary breast cancer and metastases from extramammary tumor to guide adequate treatment decision making.

Complex differential diagnosis between primary breast cancer and breast metastasis from egfr-mutated lung adenocarcinoma: Case report and literature review / C. Valenza, F.M. Porta, A. Rappa, E. Guerini-Rocco, G. Viale, M. Barberis, F. de Marinis, G. Curigliano, C. Catania. - In: CURRENT ONCOLOGY. - ISSN 1718-7729. - 28:5(2021), pp. 3384-3392. [10.3390/curroncol28050292]

Complex differential diagnosis between primary breast cancer and breast metastasis from egfr-mutated lung adenocarcinoma: Case report and literature review

C. Valenza
Primo
;
F.M. Porta
Secondo
;
E. Guerini-Rocco;G. Viale;G. Curigliano
Penultimo
;
C. Catania
Ultimo
2021

Abstract

We present a case of a woman with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who received gefitinib for 2 years and obtained a partial response. The patient then developed liver metastasis and a breast lesion, displaying high estrogen receptor (ER) expression and harboring the same EGFR mutation. From the radiological studies, it was not possible to make a differential diagnosis between primary breast cancer and breast metastasis from lung cancer. After the removal of the breast nodule, thanks to the clinical history, radiology, and above all, molecular and immunohistochemical investigations, a diagnosis of breast metastasis from lung adenocarcinoma was made. This case emphasizes the importance of a comprehensive clinical, pathological, and molecular analysis in the differential diagnosis between primary breast cancer and metastases from extramammary tumor to guide adequate treatment decision making.
Breast metastasis; EGFR-mutated lung adenocarcinoma; Lung neoplasms
Settore MED/08 - Anatomia Patologica
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/883034
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