Microsatellite instability (MSI) is observed in approximately 13% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumourigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumours. MSI caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary non-polyposis colorectal cancer syndrome but is also found in about 15% of all sporadic tumours.

Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability / G. Dionigi, V. Bianchi, F. Villa, F. Rovera, L. Boni, M. Annoni, P. Castano, R. Dionigi. - In: SURGICAL ONCOLOGY. - ISSN 0960-7404. - 16:Suppl. 1(2007), pp. 37-42. ((Intervento presentato al convegno Conference on Colorectal Cancer Biology, Diagnosis and Therapy : September, 26th - 29th tenutosi a Varese nel 2007 [10.1016/j.suronc.2007.10.018].

Differences between familial and sporadic forms of colorectal cancer with DNA microsatellite instability

G. Dionigi
Primo
;
L. Boni;
2007

Abstract

Microsatellite instability (MSI) is observed in approximately 13% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumourigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumours. MSI caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary non-polyposis colorectal cancer syndrome but is also found in about 15% of all sporadic tumours.
colorectal cancer; genes; microsatellite instability;
Settore MED/18 - Chirurgia Generale
Insubria International Summer School
Università degli studi dell'Insubria
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/882978
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