The realm of extended criteria liver transplantation created the 'adjacent possible' for dynamic organ preservation. Machine perfusion of the liver greatly expanded donor organ preservation possibilities, reaching before unattainable goals, including the mitigation of ischemia-reperfusion injury, viability assessment, and organ reconditioning prior to transplantation. However, current scientific evidence lacks uniformity between studies, perfusion protocols, and acceptance criteria. Construction of collaborative research networks for sharing knowledge should, therefore, enable the development of high-level evidence and guidelines for machine perfusion utilization, including donor acceptance criteria. Finally, this approach shall guarantee conditions for further progress to occur.

Machine perfusion of the liver : Putting the puzzle pieces together / Y.L. Boteon, P.N. Martins, P. Muiesan, A. Schlegel. - In: WORLD JOURNAL OF GASTROENTEROLOGY. - ISSN 1007-9327. - 27:34(2021), pp. 5727-5736. [10.3748/wjg.v27.i34.5727]

Machine perfusion of the liver : Putting the puzzle pieces together

P. Muiesan;
2021

Abstract

The realm of extended criteria liver transplantation created the 'adjacent possible' for dynamic organ preservation. Machine perfusion of the liver greatly expanded donor organ preservation possibilities, reaching before unattainable goals, including the mitigation of ischemia-reperfusion injury, viability assessment, and organ reconditioning prior to transplantation. However, current scientific evidence lacks uniformity between studies, perfusion protocols, and acceptance criteria. Construction of collaborative research networks for sharing knowledge should, therefore, enable the development of high-level evidence and guidelines for machine perfusion utilization, including donor acceptance criteria. Finally, this approach shall guarantee conditions for further progress to occur.
Clinical trials; Extended criteria donors; Liver preservation; Liver transplantation; Machine perfusion of the liver; Organ donation; Humans; Liver; Perfusion; Tissue Donors; Liver Transplantation; Organ Preservation
Settore MED/18 - Chirurgia Generale
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/882350
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