Purpose To prospectively analyse microperimetry, standard short-wavelength fundus autofluorescent (SWFAF) and near infrared-wavelength FAF (NIR-FAF) changes in eyes with geographic atrophy (GA) secondary to age-related macular degeneration. Methods Twenty consecutive eyes (14 patients) affected by GA were enrolled. Repeated microperimetric examinations and FAF images were obtained over a mean follow-up period of 12.3±4.5 months. Results GA area was always wider on NIR-FAF versus SW-FAF images (5.05±2.40 mm2 vs 4.45±2.41 mm2, p=0.005 baseline; 5.78±2.87 mm 2 vs 5.21±2.77 mm2, p<0.0001 follow-up). Mean retinal sensitivity significantly decreased during follow-up from 7.68±3.92 dB to 6.71±4.37 dB (p=0.0013). 47.3% of the relative dense scotomas (≤5 dB) progressed to dense scotoma (0 dB). Retinal areas showing relative dense scotoma and characterised by hypo-SW-FAF or hyper-NIR-FAF at baseline had a higher risk of evolving to dense scotoma compared with normo-FAF and hyper-FAF on SW-FAF (OR=2.62 and 2.77, respectively), or normo-FAF at NIR-FAF (OR=2.96). Conclusions SW-FAF, compared with NIR-FAF, underestimates GA area at baseline and at follow-up. The enlargement rate of progression based on NIR-FAF is not greater than on SW-FAF. Different SW-FAF and NIR-FAF patterns show different relative risk of progression from relative to dense scotoma. Microperimetry, SW-FAF and NIR-FAF should be combined to obtain adequate morphological and functional prospective information.

Fundus autofluorescence and microperimetry in progressing geographic atrophy secondary to age-related macular degeneration / E. Pilotto, F. Guidolin, E. Convento, L. Spedicato, S. Vujosevic, F. Cavarzeran, E. Midena. - In: BRITISH JOURNAL OF OPHTHALMOLOGY. - ISSN 0007-1161. - 97:5(2013), pp. 622-626. [10.1136/bjophthalmol-2012-302633]

Fundus autofluorescence and microperimetry in progressing geographic atrophy secondary to age-related macular degeneration

S. Vujosevic;
2013

Abstract

Purpose To prospectively analyse microperimetry, standard short-wavelength fundus autofluorescent (SWFAF) and near infrared-wavelength FAF (NIR-FAF) changes in eyes with geographic atrophy (GA) secondary to age-related macular degeneration. Methods Twenty consecutive eyes (14 patients) affected by GA were enrolled. Repeated microperimetric examinations and FAF images were obtained over a mean follow-up period of 12.3±4.5 months. Results GA area was always wider on NIR-FAF versus SW-FAF images (5.05±2.40 mm2 vs 4.45±2.41 mm2, p=0.005 baseline; 5.78±2.87 mm 2 vs 5.21±2.77 mm2, p<0.0001 follow-up). Mean retinal sensitivity significantly decreased during follow-up from 7.68±3.92 dB to 6.71±4.37 dB (p=0.0013). 47.3% of the relative dense scotomas (≤5 dB) progressed to dense scotoma (0 dB). Retinal areas showing relative dense scotoma and characterised by hypo-SW-FAF or hyper-NIR-FAF at baseline had a higher risk of evolving to dense scotoma compared with normo-FAF and hyper-FAF on SW-FAF (OR=2.62 and 2.77, respectively), or normo-FAF at NIR-FAF (OR=2.96). Conclusions SW-FAF, compared with NIR-FAF, underestimates GA area at baseline and at follow-up. The enlargement rate of progression based on NIR-FAF is not greater than on SW-FAF. Different SW-FAF and NIR-FAF patterns show different relative risk of progression from relative to dense scotoma. Microperimetry, SW-FAF and NIR-FAF should be combined to obtain adequate morphological and functional prospective information.
Aged; Aged, 80 and over; Disease Progression; Female; Fluorescein Angiography; Follow-Up Studies; Fundus Oculi; Geographic Atrophy; Humans; Lipofuscin; Macular Degeneration; Male; Optical Imaging; Prospective Studies; Retinal Pigment Epithelium; Risk Factors; Scotoma; Tomography, Optical Coherence; Visual Acuity; Visual Field Tests
Settore MED/30 - Malattie Apparato Visivo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/881910
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