Purpose: To evaluate the potential predictive value of the preoperative serum albumin to globulin ratio (AGR) for oncological outcomes in patients treated with radical prostatectomy (RP) for clinically non-metastatic prostate cancer (PCa). Methods: Pre-operative AGR was assessed in a multi-institutional cohort of 6041 patients treated with RP. Logistic regression analyses were performed to assess the association of the AGR with advanced disease. We performed Cox regression analyses to determine the relationship between AGR and biochemical recurrence (BCR). Results: The optimal cut-off value was determined to be 1.31 according to receiver operating curve analysis. Compared to patients with a higher AGR, those with a lower preoperative AGR had worse BCR-free survival (P < 0.01) in the Kaplan–Meier analysis. Pre- and post-operative multivariable models that adjusted for the effects of established clinicopathologic features, confirmed its independent association with BCR [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.31–1.75, P < 0.01, HR 1.55, 95% CI 1.34–1.79, P < 0.01, respectively]. However, the addition of AGR to established prognostic models did not improve their discrimination. Conclusion: While AGR is significantly associated with BCR, in the present study, the clinical impact of AGR was not large enough to affect patient management. Longer follow-up is necessary to observe the true effect of AGR.

Prognostic value of the pre-operative serum albumin to globulin ratio in patients with non-metastatic prostate cancer undergoing radical prostatectomy / A. Aydh, K. Mori, D. D'Andrea, R.S. Motlagh, M. Abufaraj, B. Pradere, H. Mostafaei, E. Laukhtina, F. Quhal, P.I. Karakiewicz, S. Luzzago, A. Briganti, Q.-. Trinh, M.K. Parizi, D. Tilki, D.V. Enikeev, S.F. Shariat. - In: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY. - ISSN 1341-9625. - 26:9(2021), pp. 1729-1735. [10.1007/s10147-021-01952-6]

Prognostic value of the pre-operative serum albumin to globulin ratio in patients with non-metastatic prostate cancer undergoing radical prostatectomy

S. Luzzago;
2021

Abstract

Purpose: To evaluate the potential predictive value of the preoperative serum albumin to globulin ratio (AGR) for oncological outcomes in patients treated with radical prostatectomy (RP) for clinically non-metastatic prostate cancer (PCa). Methods: Pre-operative AGR was assessed in a multi-institutional cohort of 6041 patients treated with RP. Logistic regression analyses were performed to assess the association of the AGR with advanced disease. We performed Cox regression analyses to determine the relationship between AGR and biochemical recurrence (BCR). Results: The optimal cut-off value was determined to be 1.31 according to receiver operating curve analysis. Compared to patients with a higher AGR, those with a lower preoperative AGR had worse BCR-free survival (P < 0.01) in the Kaplan–Meier analysis. Pre- and post-operative multivariable models that adjusted for the effects of established clinicopathologic features, confirmed its independent association with BCR [hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.31–1.75, P < 0.01, HR 1.55, 95% CI 1.34–1.79, P < 0.01, respectively]. However, the addition of AGR to established prognostic models did not improve their discrimination. Conclusion: While AGR is significantly associated with BCR, in the present study, the clinical impact of AGR was not large enough to affect patient management. Longer follow-up is necessary to observe the true effect of AGR.
Albumin; Globulin; Prostate cancer; Radical prostatectomy
Settore MED/24 - Urologia
Article (author)
File in questo prodotto:
File Dimensione Formato  
Aydh2021_Article_PrognosticValueOfThePre-operat.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 767.56 kB
Formato Adobe PDF
767.56 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/881495
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact