Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.
The microenvironment’s role in mycosis fungoides and sézary syndrome : From progression to therapeutic implications / A. Pileri, A. Guglielmo, V. Grandi, S.A. Violetti, D. Fanoni, P. Fava, C. Agostinelli, E. Berti, P. Quaglino, N. Pimpinelli. - In: CELLS. - ISSN 2073-4409. - 10:10(2021), pp. 2780.1-2780.23. [10.3390/cells10102780]
The microenvironment’s role in mycosis fungoides and sézary syndrome : From progression to therapeutic implications
S.A. Violetti;D. Fanoni;E. Berti;
2021
Abstract
Background: Mycosis fungoides (MF) and Sezary Syndrome (SS) are the most common cutaneous T-cell lymphomas. It has been hypothesized that the interaction between the immune system, cutaneous cells, and neoplastic elements may play a role in MF/SS pathogenesis and progression. Methods: This paper aims to revise in a narrative way our current knowledge of the microenvironment’s role in MF/SS. Results and Conclusions: Literature data support a possible implication of microenvironment cells in MF/SS pathogenesis and progression, opening up new therapeutic avenues.
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