ST1926 is a novel related adamantyl retinoid endowed with potent antiproliferative and apoptogenic activity. The drug induced an early G1/S cell cycle arrest which was assocd. with a typical DNA damage response including modulation of genes involved in cell cycle regulation and DNA repair. The evidence of the drug ability to induce a significant extent of DNA strand breaks after short-term exposure is consistent with the cellular response. ST1926 is active by oral administration both on hematol. and on solid tumors. The more marked antitumor effect showed by ST1926 in immuno-competent mice rather than in tumor xenografts suggests a contribution of indirect host-mediated antitumor effects in addn. to a direct antiproliferative activity against tumor cells.

Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926 / C. Pisano, L. Merlini, S. Penco, P. Carminati, F. Zunino. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 16:Suppl. 4(2004), pp. 74-76.

Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926

L. Merlini
Secondo
;
2004

Abstract

ST1926 is a novel related adamantyl retinoid endowed with potent antiproliferative and apoptogenic activity. The drug induced an early G1/S cell cycle arrest which was assocd. with a typical DNA damage response including modulation of genes involved in cell cycle regulation and DNA repair. The evidence of the drug ability to induce a significant extent of DNA strand breaks after short-term exposure is consistent with the cellular response. ST1926 is active by oral administration both on hematol. and on solid tumors. The more marked antitumor effect showed by ST1926 in immuno-competent mice rather than in tumor xenografts suggests a contribution of indirect host-mediated antitumor effects in addn. to a direct antiproliferative activity against tumor cells.
Adamantyl retinoid ; ST 1926 ; anticancer agent
Settore CHIM/06 - Chimica Organica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/8811
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