Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease.

Morphologic and molecular classification of lung neuroendocrine neoplasms / J. Metovic, M. Barella, F. Bianchi, P. Hofman, V. Hofman, M. Remmelink, I. Kern, L. Carvalho, L. Pattini, A. Sonzogni, G. Veronesi, S. Harari, F. Forest, M. Papotti, G. Pelosi. - In: VIRCHOWS ARCHIV. - ISSN 0945-6317. - 478:1(2021 Jan), pp. 5-19. [10.1007/s00428-020-03015-z]

Morphologic and molecular classification of lung neuroendocrine neoplasms

S. Harari;G. Pelosi
2021-01

Abstract

Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease.
Atypical; Carcinoid; Carcinoma; Classification; Differentiation; Gene; Large cell; Lung; Molecular; Neuroendocrine; Progression; Signature; Small cell; Stem cell; Typical
Settore MED/08 - Anatomia Patologica
21-gen-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/878569
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