Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non-linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye-based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.

Electroporation Modelling of Irregularly Nucleated Cell with Perinuclear Space / L. Mescia, P. Bia, C.M. Lamacchia, M.A. Chiapperino, A. Miani. - In: IEEE MICROWAVE MAGAZINE. - ISSN 1527-3342. - (2020 Dec), pp. 9385010.1-9385010.3. ((Intervento presentato al convegno IMBioC MTT-S International Microwave Biomedical Conference : 14th - 17th December tenutosi a Toulouse (France) nel 2020 [10.1109/IMBIoC47321.2020.9385010].

Electroporation Modelling of Irregularly Nucleated Cell with Perinuclear Space

A. Miani
Ultimo
2020

Abstract

Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non-linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye-based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.
Electroporation; Irregularly Shaped Cells; Perinuclear Space; Pore Radius Evolution; Pulsed Electric Field
Settore MED/50 - Scienze Tecniche Mediche Applicate
apr-2021
Institute of Electrical and Electronics Engineers (IEEE)
https://ieeexplore.ieee.org/abstract/document/9385010/authors#authors
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/877907
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