Background: Fenoldopam, a vasodilating agent, may represent a potential therapeutic opportunity to increase renal perfusion in those conditions where renal hemodynamics are severely impaired by vascular sub-occlusion, as, indeed, is the case in thrombotic microangiopathies. Methods: The renal resistance index (RRI) was measured, on and off fenoldopam, in 27 children with STEC-HUS. Results: A 12% decrease in RRI was observed on fenoldopam compared to off treatment without changes in the systemic hemodynamics and with no side effects. Conclusions: If confirmed in larger series, fenoldopam may become an important addition to supportive care to reduce ischemic damage in STEC-HUS and improve long-term outcomes.

Fenoldopam and renal hemodynamics in shiga toxin-related hemolytic uremic syndrome / G. Ardissino, A. Giussani, V. Capone, S. Testa, C. Gandini, G. Montini. - In: PEDIATRIC NEPHROLOGY. - ISSN 0931-041X. - 36:9(2021 Sep), pp. 2891-2894. [10.1007/s00467-021-05127-3]

Fenoldopam and renal hemodynamics in shiga toxin-related hemolytic uremic syndrome

G. Montini
Ultimo
2021-09

Abstract

Background: Fenoldopam, a vasodilating agent, may represent a potential therapeutic opportunity to increase renal perfusion in those conditions where renal hemodynamics are severely impaired by vascular sub-occlusion, as, indeed, is the case in thrombotic microangiopathies. Methods: The renal resistance index (RRI) was measured, on and off fenoldopam, in 27 children with STEC-HUS. Results: A 12% decrease in RRI was observed on fenoldopam compared to off treatment without changes in the systemic hemodynamics and with no side effects. Conclusions: If confirmed in larger series, fenoldopam may become an important addition to supportive care to reduce ischemic damage in STEC-HUS and improve long-term outcomes.
Children; Fenoldopam; Hemolytic uremic syndrome; Renal hemodynamics; Renal resistance index; Thrombotic microangiopathy
Settore MED/38 - Pediatria Generale e Specialistica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/877578
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