Immune Checkpoint Espression Associates with Rejection in Lung Transplant Recipients

The outcome of lung transplantion (LuTx) suers from a high rejection rate, and there are still huge gapsof knowledge about immune-mediated rejection mechanisms. Acute rejection (AR) can lead to chronic lungallograft dysfunction (CLAD), the main cause of poor survival and low quality of life. The standardized morphologicevaluation of rejection is based on histopathologic diagnostic criteria at a given time-point, but it has a limitedprognostic value towards clinical outcome and the likelihood to develop CLAD. We analyzed immune-check pointproteins in lung tissues of patients who received a LuTx and who were or were not undergoing rejection in theattempt to de