Feasibility of surveillance after lung transplantation using multivolume MRI instead of ionizing radioation techiques in cystic fibrosis patients

Lung transplantation (LT) is a consolidated therapy for end-stage cystic fibrosis (CF) patients. Post-LT surveillance requires several computed tomography (CT) scans, entailing a high radiological hazard for such young immunosuppressed patients. The acquisition of a conventional proton magnetic resonance (¹H-MRI) at different lung volumes has been recently used to study ventilation impairment. We aimed to investigate the use of multivolume ¹H-MRI to identify signs of lung structural damages in CF patients after LT, and to compare regional variations on ¹H-MRI with classical markers of acute lung allograft dysfunction.