BACKGROUND: In endoscopic resection of colorectal tumors, the pathological assessment of the lateral margins is a strong predictor of tumor recurrence after resection. The aim of the current study is to evaluate the value of the peritumoral margins assessment in ERBT on tumor recurrence. METHODS: We retrospectively analyzed the data of 50 consecutive patients with NMIBC and treated by ERBT between January and December 2017. RESULTS: The lateral margins showed dysplasia in 16 patients and malignancy in three patients. Local recurrence occurred in 14 (28%) patients. It was noted that 57% of patients with recurrence showed some degree of dysplasia or malignancy in the lateral margin; however, on multivariate logistic regression lateral margins lesions were not significantly associated with recurrence (OR 2.175, 95% CI : 0.430-10.996, P=0.35). CONCLUSIONS: ERBT may improve the pathological report of bladder tumor. There was a trend toward increased rate of recurrence in patients with dysplasia or malignancy in their lateral margins; however, this was not statistically significant on multivariate analysis. Further studies with larger sample sizes are required to assess the value of lateral margin analysis.

En-bloc resection of bladder tumors (ERBT) for pathological staging: the value of lateral margins analysis / A. Eissa, A. Zoeir, S. Ciarlariello, L. Sarchi, M.C. Sighinolfi, A. Ghaith, S. Puliatti, R. Inzillo, L. Reggiani Bonetti, M. Rizzo, B. Rocco, S. Micali. - In: MINERVA UROLOGICA E NEFROLOGICA. - ISSN 1827-1758. - 72:6(2020 Dec), pp. 763-769. [10.23736/S0393-2249.20.03551-1]

En-bloc resection of bladder tumors (ERBT) for pathological staging: the value of lateral margins analysis

B. Rocco
Penultimo
;
2020

Abstract

BACKGROUND: In endoscopic resection of colorectal tumors, the pathological assessment of the lateral margins is a strong predictor of tumor recurrence after resection. The aim of the current study is to evaluate the value of the peritumoral margins assessment in ERBT on tumor recurrence. METHODS: We retrospectively analyzed the data of 50 consecutive patients with NMIBC and treated by ERBT between January and December 2017. RESULTS: The lateral margins showed dysplasia in 16 patients and malignancy in three patients. Local recurrence occurred in 14 (28%) patients. It was noted that 57% of patients with recurrence showed some degree of dysplasia or malignancy in the lateral margin; however, on multivariate logistic regression lateral margins lesions were not significantly associated with recurrence (OR 2.175, 95% CI : 0.430-10.996, P=0.35). CONCLUSIONS: ERBT may improve the pathological report of bladder tumor. There was a trend toward increased rate of recurrence in patients with dysplasia or malignancy in their lateral margins; however, this was not statistically significant on multivariate analysis. Further studies with larger sample sizes are required to assess the value of lateral margin analysis.
Urinary bladder neoplasms; Colorectal neoplasms; Margins of excision; Local neoplasm recurrence;
Settore MED/24 - Urologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/876279
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