Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof‑of‑concept clinical trials, (4) neuroprognostication, (5) long‑term recovery, and (6) large datasets. This pro‑ ceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.
Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness / J. Claassen, Y. Akbari, S. Alexander, M.K. Bader, K. Bell, T.P. Bleck, M. Boly, J. Brown, S.H.-. Chou, M.N. Diringer, B.L. Edlow, B. Foreman, J.T. Giacino, O. Gosseries, T. Green, D.M. Greer, D.F. Hanley, J.A. Hartings, R. Helbok, J.C. Hemphill, H.E. Hinson, K. Hirsch, T. Human, M.L. James, N. Ko, D. Kondziella, S. Livesay, L.K. Madden, S. Mainali, S.A. Mayer, V. McCredie, M.M. McNett, G. Meyfroidt, M.M. Monti, S. Muehlschlegel, S. Murthy, P. Nyquist, D.M. Olson, J.J. Provencio, E. Rosenthal, G. Sampaio Silva, S. Sarasso, N.D. Schiff, T. Sharshar, L. Shutter, R.D. Stevens, P. Vespa, W. Videtta, A. Wagner, W. Ziai, J. Whyte, E. Zink, J.I. Suarez. - In: NEUROCRITICAL CARE. - ISSN 1541-6933. - 35:S1(2021 Jul), pp. 4-23. [10.1007/s12028-021-01260-x]
Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness
S. Sarasso;
2021
Abstract
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof‑of‑concept clinical trials, (4) neuroprognostication, (5) long‑term recovery, and (6) large datasets. This pro‑ ceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.
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