Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being frequently associated with obesity, unbalanced dietary regimens, and reduced physical activity. Despite their greater adiposity and reduced physical activity, women show a lower risk of developing NAFLD in comparison to men, likely a consequence of a sex-specific regulation of liver metabolism. In the liver, sex differences in the uptake, synthesis, oxidation, deposition, and mobilization of lipids, as well as in the regulation of inflammation, are associated with differences in NAFLD prevalence and progression between men and women. Given the major role of sex hormones in driving hepatic sexual dimorphism, this review will focus on the role of sex hormones and their signaling in the regulation of hepatic metabolism and in the molecular mechanisms triggering NAFLD development and progression.

Beyond the X Factor : relevance of sex hormones in NAFLD pathophysiology / S. Della Torre. - In: CELLS. - ISSN 2073-4409. - 10:9(2021 Sep 21), pp. 2502.1-2502.44. [10.3390/cells10092502]

Beyond the X Factor : relevance of sex hormones in NAFLD pathophysiology

S. Della Torre
2021

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being frequently associated with obesity, unbalanced dietary regimens, and reduced physical activity. Despite their greater adiposity and reduced physical activity, women show a lower risk of developing NAFLD in comparison to men, likely a consequence of a sex-specific regulation of liver metabolism. In the liver, sex differences in the uptake, synthesis, oxidation, deposition, and mobilization of lipids, as well as in the regulation of inflammation, are associated with differences in NAFLD prevalence and progression between men and women. Given the major role of sex hormones in driving hepatic sexual dimorphism, this review will focus on the role of sex hormones and their signaling in the regulation of hepatic metabolism and in the molecular mechanisms triggering NAFLD development and progression.
NAFLD; androgen receptor; androgens; estrogen receptors; estrogens; liver; metabolism; sex and gender differences; sex hormones; sexual dimorphism
Settore BIO/10 - Biochimica
Settore BIO/14 - Farmacologia
7PQ_ERC16AMAGG_CEND_M - Role of the Liver Estrogen Receptor in female Energy Metabolism, Reproduction and Aging: What About Your Liver Sexual Functions? - MAGGI, ADRIANA CATERINA - 7PQ_ERC - 7 Programma Quadro_European Research Coucil - 2013
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/871358
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