Pediatric cerebellar ataxias (PCAs) are neurological disorders characterized by impairment in motor coordination. Surprisingly, within PCA, patients with Joubert syndrome may show postural motor behaviour comparable to that of healthy subjects, probably due to the non-progressive evolution of the pathology. Indeed, remaining brain areas could cope with a stable lesion by neural plasticity. To uncover the neural substrates involved in functional compensation, we simulated whole-brain dynamics starting from a multimodal dataset within “The Virtual Brain (TVB)” framework, including or excluding the cerebro-cerebellar connections. One subject affected by Joubert syndrome and two with slow-progressive ataxia underwent diffusion and resting state fMRI to create specific structural and experimental functional connectomes (expFC). Brain dynamics were simulated for 6 minutes. Preliminary data highlighted that Pearson correlation coefficients (prediction power) between expFC and simulated FC strongly decreased not only when cerebro-cerebellar connectivity was excluded from the generation of cerebral activity but also in slow-progressive patients. This result supports the hypothesis that in patients with non-progressive disorder, the cerebellum may create new neural pathways providing compensatory strategies in brain networks. Future studies are warranted to focus on specific neural candidates that could be involved in the functional compensation.

Virtual brain modelling in cerebellar ataxic patients / S.M. Marchese, F. Palesi, M. Bruzzone, A. Nigri, S. D’Arrigo, C. Pantaleoni, C. AM Gandini Wheeler-Kingshott, E. D’Angelo, P. Cavallari. ((Intervento presentato al 71. convegno SIF national meeting tenutosi a Milano-online nel 2021.

Virtual brain modelling in cerebellar ataxic patients

S.M. Marchese;P. Cavallari
2021

Abstract

Pediatric cerebellar ataxias (PCAs) are neurological disorders characterized by impairment in motor coordination. Surprisingly, within PCA, patients with Joubert syndrome may show postural motor behaviour comparable to that of healthy subjects, probably due to the non-progressive evolution of the pathology. Indeed, remaining brain areas could cope with a stable lesion by neural plasticity. To uncover the neural substrates involved in functional compensation, we simulated whole-brain dynamics starting from a multimodal dataset within “The Virtual Brain (TVB)” framework, including or excluding the cerebro-cerebellar connections. One subject affected by Joubert syndrome and two with slow-progressive ataxia underwent diffusion and resting state fMRI to create specific structural and experimental functional connectomes (expFC). Brain dynamics were simulated for 6 minutes. Preliminary data highlighted that Pearson correlation coefficients (prediction power) between expFC and simulated FC strongly decreased not only when cerebro-cerebellar connectivity was excluded from the generation of cerebral activity but also in slow-progressive patients. This result supports the hypothesis that in patients with non-progressive disorder, the cerebellum may create new neural pathways providing compensatory strategies in brain networks. Future studies are warranted to focus on specific neural candidates that could be involved in the functional compensation.
Settore BIO/09 - Fisiologia
Società Italiana di Fisiologia
Virtual brain modelling in cerebellar ataxic patients / S.M. Marchese, F. Palesi, M. Bruzzone, A. Nigri, S. D’Arrigo, C. Pantaleoni, C. AM Gandini Wheeler-Kingshott, E. D’Angelo, P. Cavallari. ((Intervento presentato al 71. convegno SIF national meeting tenutosi a Milano-online nel 2021.
Conference Object
File in questo prodotto:
File Dimensione Formato  
Symposium_SIF2021.pdf

accesso riservato

Tipologia: Altro
Dimensione 97.15 kB
Formato Adobe PDF
97.15 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/869972
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact