Human and chimpanzee genomes are 98.8% identical within comparable sequences. However, they differ structurally in nine pericentric inversions, one fusion that originated human chromosome 2, and content and localization of heterochromatin and lineage-specific segmental duplications. The possible functional consequences of these cytogenetic and structural differences are not fully understood and their possible involvement in speciation remains unclear. We show that subtelomeric regions-regions that have a species-specific organization, are more divergent in sequence, and are enriched in genes and recombination hotspot-are significantly enriched for species-specific histone modifications that decorate transcription start sites in different tissues in both human and chimpanzee. The human lineage-specific chromosome 2 fusion point and ancestral centromere locus as well as chromosome 1 and 18 pericentric inversion breakpoints showed enrichment of human-specific H3K4me3 peaks in the prefrontal cortex. Our results reveal an association between plastic regions and potential novel regulatory elements.
Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures / G. Giannuzzi, E. Migliavacca, A. Reymond. - In: GENOME RESEARCH. - ISSN 1088-9051. - 24:9(2014), pp. 1455-1468. ((Intervento presentato al convegno American Society of Human Genetics [10.1101/gr.167742.113].
|Titolo:||Novel H3K4me3 marks are enriched at human- and chimpanzee-specific cytogenetic structures|
|Settore Scientifico Disciplinare:||Settore BIO/18 - Genetica|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1101/gr.167742.113|
|Appare nelle tipologie:||01 - Articolo su periodico|