Resveratrol, a natural product with a stilbene structure, exerts profound proapoptotic activity in human cancer cells, by triggering the accumulation of ceramide, a bioactive sphingolipid. We studied the biological effects of seven methoxylated and/or naphthalene-based resveratrol analogues and compared these compounds with resveratrol with the objective to identify an analogue with higher ceramide-mediated proapoptotic activity relative to resveratrol. Here we show that the compound with three hydroxyls and a naphthalene ring is the most effective in triggering apoptosis coupled to the induction of endogenous ceramide in human cancer cells.
|Titolo:||Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells|
|Autori interni:||GHIDONI, RICCARDO (Ultimo)|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
Settore BIO/13 - Biologia Applicata
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||10.1021/jm050528k|
|Appare nelle tipologie:||01 - Articolo su periodico|