Pediatric optic pathway gliomas (OPGs) account for 20% of brain tumors [1]. These tumors are characterized by a low-grade growth and in some cases can be associated with a tumor predisposition syndrome. In particular, 15% of patients with neurofibromatosis type 1 (NF1) develop OPGs [2]. Sporadic and NF1-associated OPGs show different outcomes and are characterized by different radiological features [3], nevertheless both forms show activation of the MAPK (mitogen-activated protein kinase) and mTOR pathways.

NF1 Gene Mutation Mediates Neuronal Signaling De-Regulation Triggering Pediatric Optic Glioma Development: Another Small Step towards a Cure of NF1 Disorder? / P. Riva, V. Tritto. - In: EC NEUROLOGY. - 13:9(2021 Aug 12), pp. 11-12.

NF1 Gene Mutation Mediates Neuronal Signaling De-Regulation Triggering Pediatric Optic Glioma Development: Another Small Step towards a Cure of NF1 Disorder?

P. Riva
Primo
Conceptualization
;
V. Tritto
Ultimo
Validation
2021-08-12

Abstract

Pediatric optic pathway gliomas (OPGs) account for 20% of brain tumors [1]. These tumors are characterized by a low-grade growth and in some cases can be associated with a tumor predisposition syndrome. In particular, 15% of patients with neurofibromatosis type 1 (NF1) develop OPGs [2]. Sporadic and NF1-associated OPGs show different outcomes and are characterized by different radiological features [3], nevertheless both forms show activation of the MAPK (mitogen-activated protein kinase) and mTOR pathways.
NF1, Optic glioma, Therapy
Settore BIO/13 - Biologia Applicata
1-set-2021
https://www.ecronicon.com/ecne/ECNE-13-00940.php
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/864593
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