A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.

Method for the preparation of micro-porous crystals and conjugates thereof / Z. Popovic, M. Matthias Tsotsalas, M. Busby, L. DE COLA, G. Calzaferri, H. Josel.

Method for the preparation of micro-porous crystals and conjugates thereof

L. DE COLA;
2008-05-08

Abstract

A conjugate comprising a dye-labeled microporous crystal, a stop-cock moiety, and covalently bound thereto an affinity binding agent is disclosed. The dye-labeled microporous crystal is a zeolite crystal, such as a zeolite L crystal, having a large number of channels in its interior into which the dye is loaded. The stop-cock moiety can be functionalized with an amino group to which a carboxyester group can be attached. The affinity binding agent allows for the binding to a biological moiety. The conjugate of the moiety can be used in in-vivo and/or in-vitro imaging applications.
ROCHE DIAGNOSTICS GMBH
F. HOFFMANN-LA ROCHE
UNIVERSITAT BERN
WO2008/052603A1
PCT/EP2007/005811
Settore CHIM/03 - Chimica Generale e Inorganica
Method for the preparation of micro-porous crystals and conjugates thereof / Z. Popovic, M. Matthias Tsotsalas, M. Busby, L. DE COLA, G. Calzaferri, H. Josel.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/864575
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact