The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.

Solvatomorphism of moxidectin / T. Grell, M. Barbero, F. Pattarino, G.B. Giovenzana, V. Colombo. - In: MOLECULES. - ISSN 1420-3049. - 26:16(2021 Aug 11), pp. 4869.1-4869.14. [10.3390/molecules26164869]

Solvatomorphism of moxidectin

T. Grell
Primo
;
V. Colombo
Ultimo
2021-08-11

Abstract

The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.
moxidectin; solvatomorphism; X-ray diffraction; variable-temperature PXRD
Settore CHIM/03 - Chimica Generale e Inorganica
Settore CHIM/02 - Chimica Fisica
PSR2015-1715FDEMA_M - PIANO DI SOSTEGNO ALLA RICERCA 2015-2017 - LINEA 2 "DOTAZIONE ANNUALE PER ATTIVITA' ISTITUZIONALE" - DEMARTIN, FRANCESCO - PSR2015-17 - Piano di sviluppo di ricerca 2015-17 - 2015
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/862519
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