The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.
Solvatomorphism of moxidectin / T. Grell, M. Barbero, F. Pattarino, G.B. Giovenzana, V. Colombo. - In: MOLECULES. - ISSN 1420-3049. - 26:16(2021 Aug 11), pp. 4869.1-4869.14. [10.3390/molecules26164869]
Solvatomorphism of moxidectin
T. GrellPrimo
;V. Colombo
Ultimo
2021
Abstract
The solvatomorphism of the anthelmintic drug moxidectin is investigated, and a new solvatomorph with nitromethane is reported. Moreover, the hitherto unknown crystal structures of the solvatomorphs with ethanol and 2-propanol are reported and discussed. The thermal characterization of these solvatomorphs through variable-temperature powder X-ray diffraction analysis (VT-PXRD) is also described, providing new insights into the crystallochemistry of this active pharmaceutical ingredient.
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