Nitric Oxide (NO) is an intracellular messenger whose diffusive properties enable an unconventional type of communication between neurons in the central nervous system that bypasses their anatomical connectivity. In this work, we modeled NO production and diffusion from a single source and investigated the range of action of the NO signal within a bioinspired spiking neural network. We found that a single active source will produce only a local effect on the individual synapse. While if multiple closely-located sources are active at the same time, NO will act more like a volume transmitter and influence even inactive synapses within that area. We focused our attention on the cerebellum's input layer, where NO is produced by the granule cells. In the granular layer, NO acts as a retrograde second messenger able to enhance presynaptic currents in the mossy fiber - granule cell synapses, thus potentiating them with long-term effects (LTP).

Production and diffusion model of nitric oxide for bioinspired spiking neural networks / A. Trapani, A. Antonietti, G. Naldi, E. D'Angelo, A. Pedrocchi (INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING). - In: 2021 10th International IEEE/EMBS Conference on Neural Engineering (NER)[s.l] : IEEE, 2021. - ISBN 9781728143378. - pp. 457-460 (( Intervento presentato al 10. convegno International IEEE/EMBS Conference on Neural Engineering, NER 2021 tenutosi a Virtual nel 2021 [10.1109/NER49283.2021.9441383].

Production and diffusion model of nitric oxide for bioinspired spiking neural networks

G. Naldi;
2021

Abstract

Nitric Oxide (NO) is an intracellular messenger whose diffusive properties enable an unconventional type of communication between neurons in the central nervous system that bypasses their anatomical connectivity. In this work, we modeled NO production and diffusion from a single source and investigated the range of action of the NO signal within a bioinspired spiking neural network. We found that a single active source will produce only a local effect on the individual synapse. While if multiple closely-located sources are active at the same time, NO will act more like a volume transmitter and influence even inactive synapses within that area. We focused our attention on the cerebellum's input layer, where NO is produced by the granule cells. In the granular layer, NO acts as a retrograde second messenger able to enhance presynaptic currents in the mossy fiber - granule cell synapses, thus potentiating them with long-term effects (LTP).
Settore MAT/08 - Analisi Numerica
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore BIO/09 - Fisiologia
Blackrock Microsystems
et al.
Instituto Italiano di Tecnologia
Medtronic
The Biorobotics Institute, Sant'Anna School of Advanced Studies - Pisa
University of Houston, Cullen College of Engineering, Department of Biomedical Engineering
Book Part (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/861762
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