Aim To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and Methods This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes : A prospective, multicentre, real-life study / V. Cherubini, I. Rabbone, M. Berioli, S. Giorda, D. Lo Presti, G. Maltoni, C. Mameli, M. Marigliano, M. Marino, N. Minuto, E. Mozzillo, E. Piccinno, B. Predieri, C. Ripoli, R. Schiaffini, A. Rigamonti, G. Salzano, D. Tinti, S. Toni, A. Zanfardino, A. Scaramuzza, R. Gesuita, V. Tiberi, S. Savastio, C. Pigniatiello, M. Trada, S. Zucchini, F. Redaelli, C. Maffeis, M. Bassi, F. Rosanio, M. Delvecchio, P. Buzzi, M. Ricciardi, C. Carducci, R. Bonfanti, F. Lombardo, B. Piccini, D. Iafusco, M. Calandretti, F. Daga. - In: DIABETES, OBESITY AND METABOLISM. - ISSN 1462-8902. - (2021 Jul 06). [Epub ahead of print] [10.1111/dom.14491]

Effectiveness of a closed-loop control system and a virtual educational camp for children and adolescents with type 1 diabetes : A prospective, multicentre, real-life study

C. Mameli;F. Redaelli;
2021-07-06

Abstract

Aim To evaluate the impact of a virtual educational camp (vEC) on glucose control in children and adolescents with type 1 diabetes using a closed-loop control (CLC) system. Materials and Methods This was a prospective multicentre study of children and adolescents with type 1 diabetes using the Tandem Basal-IQ system. Insulin pumps were upgraded to Control-IQ, and children and their parents participated in a 3-day multidisciplinary vEC. Clinical data, glucose metrics and HbA1c were evaluated over the 12 weeks prior to the Control-IQ update and over the 12 weeks after the vEC. Results Forty-three children and adolescents (aged 7-16 years) with type 1 diabetes and their families participated in the vEC. The median percentage of time in target range (70-180 mg/dL; TIR) increased from 64% (interquartile range [IQR] 56%-73%) with Basal-IQ to 76% (IQR 71%-81%) with Control-IQ (P < .001). After the vEC, more than 75% of participants achieved a TIR of more than 70%. The percentage of time between 180 and 250 mg/dL and above 250 mg/dL decreased by 5% (P < .01) and 6% (P < .01), respectively, while the time between 70 and 54 mg/dL and below 54 mg/dL remained low and unaltered. HbA1c decreased by 0.5% (P < .01). There were no episodes of diabetic ketoacidosis or severe hypoglycaemia. Conclusions In this study of children managing their diabetes in a real-world setting, more than 75% of children who participated in a vEC after starting a CLC system could obtain and maintain a TIR of more than 70%. The vEC was feasible and resulted in a significant and persistent improvement in TIR in children and adolescents with type 1 diabetes.
continuous glucose monitoring; CSII; glycaemic control; insulin pump therapy; observational study; type 1 diabetes
Settore MED/38 - Pediatria Generale e Specialistica
6-lug-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/861537
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