During this pandemic, dermatological infusion centers were partially unavailable, suspended or even reconverted to guest COVID-19 patients, consequently infliximab infusions became challenging for their both logistic arrangement and also for patients' COVID-19 phobia. This 48 weeks follow-up retrospective observational study included 37 PsO patients that underwent IFX SB2 during pandemic in two primary dermatological referral centers. In 23 (62.1%) we had to switch from IFX to other biologics, not motivated by adverse reactions, contraindication or even loss of response but only to pandemic related conditions. Nine patients underwent interclass switching and 15 underwent intraclass switching; interestingly 2 patients that underwent adalimumab SB-5 had to switch back to IFX. Interclass switching was privileged in elder patients and smokers. All patients at weeks achieved PASI 100. Intra- and interclass switchings are both safe and effective strategies in psoriatic patients with COVID-19 phobia and/or difficulties to undergo infliximab infusions. This article is protected by copyright. All rights reserved.

Switching infliximab in psoriatic patients during COVID ‐19 pandemics: a real‐life retrospective study comparing intra‐ vs interclass switching strategies / A. Conti, G. Damiani, R. Ruggeri, G. Odorici, F. Farnetani, P.D.M. Pigatto, G. Pellacani. - In: DERMATOLOGIC THERAPY. - ISSN 1396-0296. - (2021), pp. e15088.1-e15088.5. [Epub ahead of print] [10.1111/dth.15088]

Switching infliximab in psoriatic patients during COVID ‐19 pandemics: a real‐life retrospective study comparing intra‐ vs interclass switching strategies

G. Damiani
Co-primo
Conceptualization
;
P.D.M. Pigatto
Penultimo
;
2021

Abstract

During this pandemic, dermatological infusion centers were partially unavailable, suspended or even reconverted to guest COVID-19 patients, consequently infliximab infusions became challenging for their both logistic arrangement and also for patients' COVID-19 phobia. This 48 weeks follow-up retrospective observational study included 37 PsO patients that underwent IFX SB2 during pandemic in two primary dermatological referral centers. In 23 (62.1%) we had to switch from IFX to other biologics, not motivated by adverse reactions, contraindication or even loss of response but only to pandemic related conditions. Nine patients underwent interclass switching and 15 underwent intraclass switching; interestingly 2 patients that underwent adalimumab SB-5 had to switch back to IFX. Interclass switching was privileged in elder patients and smokers. All patients at weeks achieved PASI 100. Intra- and interclass switchings are both safe and effective strategies in psoriatic patients with COVID-19 phobia and/or difficulties to undergo infliximab infusions. This article is protected by copyright. All rights reserved.
Biologics; COVID-19 pandemic; Infliximab; Interclass switching; Intraclass switching; Psoriasis; Switching; Teledermatology
Settore MED/35 - Malattie Cutanee e Veneree
ago-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/861396
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