This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype (p < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis (p < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCR β-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity.

Sex-related differences in allelic frequency of the human beta T cell receptor SNP rs1800907: A retrospective analysis from milan metropolitan area / E.M. Varoni, G. Lodi, M. Del Fabbro, A. Sardella, A. Carrassi, M. Iriti, P. Tripputi. - In: VACCINES. - ISSN 2076-393X. - 9:4(2021 Apr), pp. 333.1-333.8. [10.3390/vaccines9040333]

Sex-related differences in allelic frequency of the human beta T cell receptor SNP rs1800907: A retrospective analysis from milan metropolitan area

E.M. Varoni
Primo
;
G. Lodi
Secondo
;
M. Del Fabbro;A. Sardella;A. Carrassi;M. Iriti
Penultimo
;
P. Tripputi
Ultimo
2021-04

Abstract

This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype (p < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis (p < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCR β-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity.
Genotype distribution; Heterozygosis; Homozygosis; Polymorphism
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/28 - Malattie Odontostomatologiche
Settore MED/09 - Medicina Interna
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/861142
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