BACKGROUNDIntestinal metastases from breast cancer (BC) arerare; available data depend mainly on case reports and case series.AIMTo conduct a review of the literature regarding presentation, diagnosis, treatment and survival of patients with intestinal metastasis from BC.METHODSWe identified all articles that described patients with intestinal metastasis (from duodenum to anum) from BC using MEDLINE (1975 to 2020) and EMBASE (1975 to 2020) electronic databases.RESULTSWe found 96 cases of intestinal metastasis of BC. Metastasization involved large bowel (cecum, colon, sigmoid, rectum) (51%), small bowel (duodenum, jejunum, ileum) (49%), and anum (< 1%). Median age of patients was 61-years. The most frequent histology was infiltrating lobular carcinoma followed by infiltrating ductal carcinoma. In more than half of patients, the diagnosis was made after the diagnosis of BC (median: 7.2 years) and in many cases of emergency, for bowel obstruction, bleeding or perforation. Diagnosis was achieved through endoscopy, radiological examination or both. In most of the cases, patients underwent surgery with or without systemic therapies. Survival of patients included in this review was available in less than 50% of patients and showed an overall median of 12 mo since diagnosis of the intestinal metastasis.CONCLUSIONAlthough, intestinal metastases of BC are considered a rare condition, clinicians should consider the possibility of intestinal involvement in case of abdominal symptoms even in acute setting and many years after the diagnosis of BC, especially in patients with a histology of lobular carcinoma.

Intestinal metastasis from breast cancer: Presentation, treatment and survival from a systematic literature review / E. Bolzacchini, O. Nigro, D. Inversini, M. Giordano, G. Maconi. - In: WORLD JOURNAL OF CLINICAL ONCOLOGY. - ISSN 2218-4333. - 12:5(2021), pp. 382-392. [10.5306/wjco.v12.i5.382]

Intestinal metastasis from breast cancer: Presentation, treatment and survival from a systematic literature review

G. Maconi
2021

Abstract

BACKGROUNDIntestinal metastases from breast cancer (BC) arerare; available data depend mainly on case reports and case series.AIMTo conduct a review of the literature regarding presentation, diagnosis, treatment and survival of patients with intestinal metastasis from BC.METHODSWe identified all articles that described patients with intestinal metastasis (from duodenum to anum) from BC using MEDLINE (1975 to 2020) and EMBASE (1975 to 2020) electronic databases.RESULTSWe found 96 cases of intestinal metastasis of BC. Metastasization involved large bowel (cecum, colon, sigmoid, rectum) (51%), small bowel (duodenum, jejunum, ileum) (49%), and anum (< 1%). Median age of patients was 61-years. The most frequent histology was infiltrating lobular carcinoma followed by infiltrating ductal carcinoma. In more than half of patients, the diagnosis was made after the diagnosis of BC (median: 7.2 years) and in many cases of emergency, for bowel obstruction, bleeding or perforation. Diagnosis was achieved through endoscopy, radiological examination or both. In most of the cases, patients underwent surgery with or without systemic therapies. Survival of patients included in this review was available in less than 50% of patients and showed an overall median of 12 mo since diagnosis of the intestinal metastasis.CONCLUSIONAlthough, intestinal metastases of BC are considered a rare condition, clinicians should consider the possibility of intestinal involvement in case of abdominal symptoms even in acute setting and many years after the diagnosis of BC, especially in patients with a histology of lobular carcinoma.
Breast cancer; Intestinal metastasis; Diagnosis; Treatment; Small bowel; Large bowel
Settore MED/12 - Gastroenterologia
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/860221
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