IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishWe investigated Lp(a) levels and apo(a) polymorphism in relation to the severity of coronary artery disease, expressed both by the number of coronary arteries stenosed and three different coronary scoring systems. In a sample of 267 patients with coronary artery disease, a Mono-, Bi- or Multi-vessel coronary stenosis was documented by angiography. Twenty-five apo(a) isoforms were detected by a high resolution phenotyping method. Lp(a) levels did not show any differences among subgroups of patients. Both the percentage of apo(a) isoforms of low molecular weight (<655 kDa) (P=0.00015) and the percentage of subjects with at least one apo(a) isoform of low molecular weight (P=0.00027) were significantly correlated with increasing number of coronary vessels stenosed. In multivariate analysis, only apo(a) isoforms of low molecular weight were predictors of coronary atherosclerosis severity, when we used as the dependent variable both the '1-2-multi-vessels' categorization (P=0.000067) and the Gensini (P=0.008767), or Green Lane (P= 0.000001) or Dahlen (P=0.000102) coronary scoring system. Our data show that apo(a) isoforms of low molecular weight are associated with a greater severity of coronary atherosclerosis. If these data are confirmed by prospective studies, apo(a) phenotypes might be used as genetic markers of a greater severity of coronary atherosclerotic lesions.
Apolipoprotein(a) phenotypes as genetic markers of coronary atherosclerosis severity / C. Gazzaruso, D. Geroldi, A. Garzaniti, C. Falcone, P. Fratino, G. Finardi, P. Buscaglia. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 64:3(1998), pp. 277-284. [10.1016/S0167-5273(98)00050-3]
| Titolo: | Apolipoprotein(a) phenotypes as genetic markers of coronary atherosclerosis severity | |
| Autori: | ||
| Parole Chiave: | Apolipoprotein(a) polymorphism; Atherosclerosis; Coronary disease; Lipoprotein(a) | |
| Settore Scientifico Disciplinare: | Settore MED/13 - Endocrinologia Settore MED/09 - Medicina Interna Settore MED/11 - Malattie dell'Apparato Cardiovascolare | |
| Data di pubblicazione: | 1998 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0167-5273(98)00050-3 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 1998 Int J Cardiol apoa CAD severity.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
Pubblicazioni consigliate
Copyright © 2022